What Is Harvoni (Ledipasvir and Sofosbuvir)?
Harvoni is the brand name for a prescription drug that contains the active ingredients ledipasvir and sofosbuvir.
Doctors prescribe Harvoni to treat the most common form of hepatitis C — chronic hepatitis C genotype 1 — which accounts for up to 75 percent of all hepatitis C infections.
Harvoni belongs to a group of drugs known as antivirals. Both active ingredients in Harvoni prevent the hepatitis C virus from reproducing.
Manufactured by Gilead Sciences, Harvoni was approved by the Food and Drug Administration (FDA) in 2014.
Currently, there's no generic version available.
Don't take Harvoni if you're allergic to either of Harvoni's active ingredients, or to any other ingredients found in the drug.
While Harvoni's effectiveness doesn't seem to be affected by impaired kidney function, ask your doctor about Harvoni before taking the drug if you have severe kidney problems or are on dialysis.
Pregnancy and Harvoni
The effects of Harvoni on a pregnant woman's unborn child have not been studied.
If you're pregnant or might become pregnant, you and your doctor should discuss the risks and benefits of the drug.
Scientists aren't sure whether Harvoni passes into human breast milk, and its effect on breastfeeding babies is unknown.
Ask your doctor about Harvoni if you're breastfeeding.
It's always a good idea to talk to your doctor about all medications you're taking if you're pregnant, planning a pregnancy, or breastfeeding.
Harvoni Side Effects
Common Side Effects
Tell your doctor if any of the following side effects are severe or don't go away:
- Increased tiredness
- Trouble sleeping
Serious Side Effects
While no major side effects of taking Harvoni have been reported, serious side effects are still a possibility.
Talk with your doctor, or seek immediate medical care, if you experience any severe health conditions.
Tell your doctor and pharmacist about all prescription, over-the-counter, illegal, recreational, herbal, nutritional, or vitamin-containing drugs and supplements you're taking.
You shouldn't take Harvoni if you're taking any of the following drugs:
Other drugs that may have serious interactions with Harvoni include:
Harvoni and Alcohol
Drinking alcohol can worsen existing liver disease.
Since doing so essentially works against Harvoni's benefits, limit or avoid the use of alcohol while taking Harvoni.
Harvoni and Grapefruit Juice
Harvoni is a relatively new drug, and scientists aren't sure whether the liver breaks down Harvoni the same way as certain chemicals found in grapefruit.
To avoid any possible interactions, avoid grapefruit and grapefruit juice while taking Harvoni.
Each tablet of Harvoni contains 90 milligrams (mg) of ledipasvir and 400 mg of sofosbuvir.
Take one tablet every day with or without food.
How long your doctor tells you to take Harvoni will depend on how severe your liver damage is and whether you've taken Harvoni in the past.
For example, if you've never taken Harvoni, your doctor may prescribe an 8 or a 12-week course of Harvoni — regardless of whether you have irreversible liver damage (cirrhosis).
Your doctor may tell you to take Harvoni for up to 24 weeks if you have liver cirrhosis and have taken Harvoni in the past.
If you suspect an overdose of Harvoni, contact an emergency room or poison control center right away.
You can reach a poison control center at 800-222-1222.
Missed Dose of Harvoni
If you miss a dose of Harvoni, take it as soon as you remember.
However, if it's almost time for your next dose, skip the missed dose and take your next dose at the regular time.
Don't double up on doses to make up for a missed one.
Video: Harvoni Hepatitis C Treatment - End of Treatment Results
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